Windows systems updates should not affect Spine.
Are all your users on Windows? We've never had reports about issues with multiple monitors on Windows.
On macOS some users have reported problems from having multiple monitors connected. Usually it can be solved by disconnecting the second monitor, starting Spine, then reconnecting the second monitor. macOS software related to multiple monitors, like "DisplayLink", is known to cause problems with the Spine and should not be used.
I'm not sure what would cause not being able to lock the file C:\Users\hhh\Spine\settings\start-1.json. Spine locks this file, reads it, then unlocks it. Make sure you don't have any Spine.exe processes running, kill them if you do, as an old process may be locking the file. Otherwise anti-virus or similar may be locking the file, or the user doesn't have permissions to the file or the parent folders its in.
